On October 16 1843, the Irish mathematician William Rowan Hamilton had an epiphany during a walk alongside Dublin’s Royal Canal. He was so excited he took out his penknife and carved his discovery ...

The CD40–CD40L costimulatory pathway regulates adaptive and innate immune responses and has been implicated in the pathogenesis of multiple sclerosis. Frexalimab is a second-generation anti-CD40L ...