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Multiple myeloma (MM) treatment has changed tremendously, with significant improvement in patient out-comes. One group with a suboptimal benefit is patients with high-risk cytogenetics, as tested by ...

EM, biochemical, and cell-based assays to examine how Gβγ interacts with and potentiates PLCβ3. The authors present evidence for multiple Gβγ interaction surfaces and argue that Gβγ primarily enhances ...

The dorsal raphe nucleus (DRN) serotonergic (5-HT) system has been implicated in regulating sleep and motor control; however, its specific role remains controversial. In this study, we found that ...

BACKGROUND: Preeclampsia affects approximately 1 in 10 pregnancies, leading to severe complications and long-term health ...

BACKGROUND: Genetic variants in components or regulators of the RAS-MAPK signaling pathway are causative for severe and early-onset hypertrophic cardiomyopathy (HCM) in patients with Noonan syndrome ...

Background Current automatic software uses a fixed apparent diffusion coefficient (ADC) threshold (≤620×10⁻⁶ mm²/s) to ...

BEATRICE and Eugenie will skip Easter’s major Royal Family gathering – their first chance to appear together since the Epstein files dropped with damaging claims about their father. The two princesses ...

Background/aims Ocular surface infections remain a major cause of visual loss worldwide, yet diagnosis often relies on slow ...